When World War II broke the Quintet was touring England. Django and other returned to Paris but Grappelli stayed in England thus ending the first incarnation of the Quintette du Hot Club de France. Clarinettist Hubert Rostaing was hired to replace Grappelli. Django somehow survived the dark years of Nazi rule when many of his people perished in concentration camps. Jazz was banned under Hitler.

Django was only allowed to play his music because of the aid of a Luftwaffe official who loved jazz and admired his skill. After the war he rejoined Grappelli and they continued to tour.  Django visited the US alone  in 1946 with Duke Ellington. He stayed in New York for a while but in 1948 returned to France and played mostly electric guitar except on his later days masterpiece Djangology which he recorded in Rome together with Grappelli and a trio of Italian musicians.

In 1951 he retired to to Samois sur Seine, near Fontainebleau France. He lived there until May 16, 1953, when, collapsed outside his house and was declared dead from a brain haemorrhage on arrival at the hospital in Fontainebleau.